P1: CHOLINERGIC RECEPTOR FUNCTION IN CARDIAC ISCHEMIC PRECONDITIONING

Effect of endogenous nitric oxide on cardiac ischemic preconditioning in rat

Introduction: Ischemic Preconditioning (IPC) is the phenomen that happens on the heart by one or several short periods of ischemia followed by reperfusion that improve the postischemic recovery of mechanical function. Ischemic preconditioning (IPC) may protect the heart from ischemia reperfusion injury by nitric oxide formation. This study investigated the effect of ischemic preconditioni...

Remote Ischemic Preconditioning and Cardiac Surgery.

To the Editor: Remote ischemic preconditioning (RIPC) is an inexpensive technique that is used to reduce perioperative organ damage. High-quality randomized trials have shown cardiac1 and renal2 protection with a possible reduction in mortality when RIPC was used in addition to halogenated agents.3 However, two recent multicenter, randomized trials, the Remote Ischemic Preconditioning for Heart...

Remote Ischemic Preconditioning for Cardiac Surgery

Remote Ischemic Preconditioning for Cardiac Surgery

Ever since its discovery more than 2 decades ago, remote ischemic preconditioning (RIPC) has generated tremendous interest among scientists and clinicians alike. However, two recent large, well-conducted, randomized controlled trials (RCTs) have failed to identify any significant benefit of RIPC during cardiac surgery. A reconciliatory yet objective review of cumulative evidence with regard to ...

Ischemic preconditioning exaggerates cardiac damage in PKC- null mice

Manuel Mayr, Bernhard Metzler, Yuen-Li Chung, Emma McGregor, Ursula Mayr, Helen Troy, Yanhua Hu, Michael Leitges, Otmar Pachinger, John R. Griffiths, Michael J. Dunn, and Qingbo Xu Department of Cardiac and Vascular Sciences and Department of Basic Medical Sciences, St. George’s Hospital Medical School, London SW17 0RE, United Kingdom; Division of Cardiology, Department of Internal Medicine, Un...